Description
Kisspeptin-10 Technical Overview
Kisspeptin-10 is a synthetic decapeptide corresponding to the biologically active C-terminal region of kisspeptin, a peptide family derived from the KISS1 gene.
The peptide activates the kisspeptin receptor KISS1R, also known as GPR54, and has been investigated in reproductive endocrinology research.
Scientific investigations have examined Kisspeptin-10-associated GnRH neuronal activation and signaling within the hypothalamic-pituitary-gonadal axis.
Compound Specifications
| Property | Value |
|---|---|
| Compound Name | Kisspeptin-10 |
| Alternative Name | Metastin 45–54 |
| CAS Number | 374675-21-5 |
| Sequence | YNWNSFGLRF-NH2 |
| Sequence Length | 10 amino acids |
| Primary Receptor | KISS1R / GPR54 |
| Classification | Kisspeptin receptor agonist |
| Vial Content | 5mg |
Storage and Handling
- Follow manufacturer storage recommendations.
- Protect from moisture, direct light, and contamination.
- Use suitable laboratory peptide handling procedures.
Lyophilized Format
Kisspeptin-10 may be prepared in lyophilized form. Its stability depends on formulation and packaging.
Research Use Disclaimer
Kisspeptin-10 is not FDA-approved for human therapeutic use. Not intended for human or veterinary administration.
Frequently Asked Questions
What Is Kisspeptin-10?
A ten-residue peptide derived from the active region of kisspeptin.
What Is Its Sequence?
YNWNSFGLRF-NH2.
Which Receptor Does It Activate?
KISS1R.
What Research Areas Involve Kisspeptin-10?
GnRH signaling, reproductive endocrine regulation, and receptor pharmacology.
Kisspeptin-10 Research Overview
Kisspeptin signaling is an important component of reproductive neuroendocrine regulation.
KISS1R Research
Laboratory studies characterize receptor activation and downstream signaling.
GnRH Neuronal Research
Research examines relationships between kisspeptin signaling and GnRH activity.
Reproductive Endocrinology
Experimental investigations evaluate pathways involved in gonadotropin regulation.
Research Applications
| Research Area | In Vitro Application |
|---|---|
| KISS1R | Receptor activation assays |
| GnRH Signaling | Neuronal response studies |
| Endocrine Biology | Hormonal signaling pathway analysis |
References
- Messager S, et al. (2005). Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. PNAS. View publication.
Certificate of Analysis (COA)
Documentation should establish peptide identity, C-terminal amidation, purity, and content.
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