Description
Teriparatide Technical Overview
Teriparatide is a synthetic 34-amino-acid peptide corresponding to the biologically active N-terminal fragment of human parathyroid hormone, PTH(1–34).
It binds to the parathyroid hormone 1 receptor (PTH1R), a class B G protein-coupled receptor involved in calcium regulation and bone remodeling.
Teriparatide has been investigated extensively in bone biology and endocrine research involving osteoblast signaling, cyclic AMP pathways, and skeletal remodeling.
Compound Specifications
| Property | Value |
|---|---|
| Compound Name | Teriparatide |
| Alternative Name | Human PTH(1–34) |
| CAS Number | 52232-67-4 |
| Sequence Length | 34 amino acids |
| Classification | Parathyroid hormone fragment |
| Research Receptor | PTH1R |
| Research Category | Bone and Endocrine Research |
| Vial Content | 10mg |
Storage and Handling
- Follow manufacturer-specific stability conditions.
- Protect from contamination and environmental stress.
- Use suitable peptide handling procedures.
Lyophilized Format
Teriparatide may be manufactured in lyophilized form. Stability depends on its formulation and packaging.
Research Use Disclaimer
FDA-approved prescription Teriparatide products exist. This research material is not represented as an approved pharmaceutical product and is not intended for human or veterinary administration.
Frequently Asked Questions
What Is Teriparatide?
A synthetic 34-amino-acid fragment of human parathyroid hormone.
Which Receptor Does It Activate?
PTH1R.
Is Teriparatide Full-Length PTH?
No. It contains the first 34 residues of the 84-residue parent hormone.
What Research Areas Involve Teriparatide?
Bone remodeling, osteoblast signaling, and PTH1R pharmacology.
Is This Research Vial FDA-Approved?
No approval is established for this preparation.
Research Overview
Teriparatide is an extensively characterized PTH1R ligand used in bone and endocrine research.
PTH1R Signaling
Research examines receptor activation and downstream cAMP signaling.
Osteoblast Biology
Experimental investigations evaluate osteoblast-associated cellular processes.
Bone Remodeling Research
Studies characterize the regulation of bone formation and remodeling pathways.
Research Applications
| Research Area | In Vitro Application |
|---|---|
| PTH1R | Receptor activation assays |
| Osteoblasts | Cell signaling studies |
| Bone Biology | Remodeling pathway research |
References
- Neer RM, Arnaud CD, Zanchetta JR, et al. (2001). Effect of Parathyroid Hormone (1–34) on Fractures and Bone Mineral Density in Postmenopausal Women With Osteoporosis. New England Journal of Medicine. View publication.
Certificate of Analysis (COA)
Documentation should verify peptide identity, sequence, purity, and vial content. Peptide Lives.
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