Description
FOXO4 Technical Overview
FOXO4 is a member of the Forkhead Box O family of transcription factors involved in cellular stress responses, gene regulation, and cell survival.
In peptide research, the name FOXO4 is frequently associated with FOXO4-DRI, an engineered D-retro-inverso peptide investigated for its ability to interfere with interactions between FOXO4 and the tumor suppressor protein p53.
Research published in Cell in 2017 examined FOXO4-DRI in experimental models of cellular senescence. The investigators reported changes in senescent cell survival and selected physiological outcomes in mice.
The complete molecular identity of the Peptide Lives FOXO4 preparation must be confirmed before FOXO4-DRI-specific findings are assigned to the product.
Compound Specifications
| Property | Value |
|---|---|
| Product Name | FOXO4 |
| Related Research Compound | FOXO4-DRI |
| Compound Classification | FOXO4-derived research peptide, pending identification |
| Research Proteins | FOXO4 and p53 |
| Sequence | Requires manufacturer confirmation |
| Stereochemistry | Requires manufacturer confirmation |
| Molecular Formula | Requires manufacturer confirmation |
| Molecular Weight | Requires manufacturer confirmation |
| Product Strength | 10mg |
| Research Category | Cellular Senescence Research |
FOXO4 is the name of a natural transcription factor. FOXO4-DRI is a specific synthetic peptide construct. These identifiers are not interchangeable without structural verification.
Storage and Handling
- Store according to manufacturer-validated stability conditions.
- Keep the compound protected from moisture and direct light.
- Avoid unnecessary temperature changes.
- Follow handling procedures appropriate for the verified peptide structure.
Lyophilized Format
FOXO4-derived synthetic peptides may be supplied in lyophilized form. The physical state and stability requirements of this preparation must be verified against batch documentation.
Research Use Disclaimer
FOXO4-derived experimental peptides are not FDA-approved for anti-aging or other therapeutic uses. Research involving FOXO4-DRI does not establish clinical safety or effectiveness in humans. This material is not intended for human or veterinary administration.
Frequently Asked Questions
What Is FOXO4?
FOXO4 is a transcription factor involved in cellular signaling and gene regulation.
What Is FOXO4-DRI?
FOXO4-DRI is an engineered research peptide investigated for disruption of FOXO4-p53 interactions.
What Is Cellular Senescence?
Cellular senescence is a biological state characterized by stable cell-cycle arrest and changes in cellular signaling.
What Research Areas Involve FOXO4-DRI?
Research includes cellular senescence, p53 signaling, apoptosis, and experimental aging models.
Is FOXO4-DRI an Approved Anti-Aging Treatment?
No. Preclinical research has not established FOXO4-DRI as a safe or effective human anti-aging treatment.
Research Overview
The FOXO4 transcription factor has been studied for its role in cellular stress responses. Research into cellular senescence has investigated interactions between FOXO4 and p53, a protein involved in cell-cycle regulation and apoptosis.
FOXO4-DRI was developed as an experimental peptide intended to disrupt selected FOXO4-p53 interactions.
FOXO4-p53 Interaction Research
Experimental studies investigated whether interfering with FOXO4-p53 binding could alter signaling in senescent cells.
Cellular Senescence Research
Research published in 2017 reported that FOXO4-DRI promoted apoptosis in selected senescent cell populations.
Apoptosis Research
The original experimental study investigated p53 localization and cell death pathways following FOXO4-DRI exposure.
Animal Aging Research
Studies in mice reported changes in selected tissue-related and physiological measurements following experimental FOXO4-DRI exposure.
These findings do not establish that FOXO4-DRI extends human lifespan or reverses human aging.
Research Applications
| Research Area | In Vitro Application |
|---|---|
| FOXO4-p53 Research | Protein interaction assays |
| Cellular Senescence | Senescent cell survival measurements |
| Apoptosis Research | Cell death pathway analysis |
| Stress Signaling | Cellular response investigations |
References
- Baar MP, Brandt RMC, Putavet DA, et al. (2017). Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell. PubMed PMID: 28340339.
Certificate of Analysis (COA)
Before interpreting this product as FOXO4-DRI, researchers should verify its complete sequence, D-retro-inverso stereochemistry, molecular identity, purity, and compound content.
For information about available documentation, contact Peptide Lives.
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