Description
DSIP Technical Overview
Delta Sleep-Inducing Peptide (DSIP), also known as Emideltide, is a nine-amino-acid peptide originally characterized during investigations of sleep-associated electroencephalographic activity.
The peptide was isolated from rabbit cerebral venous blood in experiments involving electrically induced sleep-related brain activity.
Its amino acid sequence, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, was established in research published during the 1970s.
Early experimental studies reported changes in delta-wave and sleep-spindle electroencephalographic patterns following DSIP exposure in rabbits.
Subsequent investigations have produced inconsistent findings, and DSIP has not been established as a reliable sleep-promoting compound in humans.
The endogenous biological origin, specific receptor, and primary physiological mechanisms associated with DSIP remain incompletely understood.
Compound Specifications
| Property | Value |
|---|---|
| Compound Name | Delta Sleep-Inducing Peptide |
| Alternative Names | DSIP, Emideltide |
| CAS Number | 62568-57-4 |
| PubChem CID | 68816 |
| Molecular Formula | C35H48N10O15 |
| Molecular Weight | 848.81 g/mol |
| Amino Acid Sequence | H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH |
| One-Letter Sequence | WAGGDASGE |
| Sequence Length | 9 amino acid residues |
| Peptide Structure | Linear nonapeptide |
| Confirmed Specific Receptor | Not established |
| Source | Synthetic research preparation |
| Vial Content | 15mg |
| Research Category | Neuropeptide Research |
The molecular specifications describe the unmodified DSIP nonapeptide. Salt forms and terminal modifications may alter overall molecular composition.
Storage and Handling
- Store according to the manufacturer’s validated stability recommendations.
- Protect the material from unnecessary moisture and light exposure.
- Keep containers securely closed.
- Minimize temperature fluctuations.
- Follow established laboratory procedures for peptide handling.
Lyophilized Format
DSIP may be manufactured as a lyophilized research peptide.
Freeze-drying can reduce moisture content and support stability under suitable conditions.
The physical form and storage characteristics of the specific preparation should be confirmed through manufacturer documentation.
Research Use Disclaimer
DSIP is not FDA-approved as a sleep medication or for other human therapeutic applications.
This compound is described exclusively for laboratory research and is not intended for human or veterinary administration.
Frequently Asked Questions
What Is DSIP 15mg?
DSIP 15mg is a research preparation of Delta Sleep-Inducing Peptide, a synthetic nine-amino-acid peptide.
What Is the Amino Acid Sequence of DSIP?
The sequence is WAGGDASGE, corresponding to Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
What Are the CAS Number and Molecular Weight?
DSIP has CAS number 62568-57-4 and a molecular weight of approximately 848.81 g/mol.
What Research Areas Involve DSIP?
DSIP has been studied in research involving sleep-associated EEG patterns, neuropeptide biology, and experimental neural signaling.
Does DSIP Have a Confirmed Receptor?
No specific DSIP receptor has been conclusively established.
Is DSIP Proven to Improve Human Sleep?
No. Available human and animal findings are inconsistent and do not establish reliable clinical effectiveness.
Research Overview
DSIP was identified during experimental investigations of sleep-related electroencephalographic activity.
Early research in rabbits demonstrated increased delta and spindle EEG activity under specific experimental conditions.
Subsequent scientific investigations attempted to characterize its physiological role, but the peptide’s mechanism and relationship to normal sleep regulation remain unresolved.
Delta-Wave EEG Research
Original experiments examined changes in electroencephalographic activity following DSIP exposure in rabbits.
The researchers reported increased delta-wave activity and changes in sleep-spindle patterns.
Neuropeptide Signaling Research
DSIP has been investigated as a potential neuroactive peptide, although its receptor and endogenous signaling pathway have not been conclusively identified.
Sleep Physiology Research
Experimental and clinical studies have evaluated DSIP-associated changes in sleep-related measurements.
Results have been inconsistent, and subsequent research has not confirmed a reliable sleep-promoting effect in humans.
Peptide Structure Research
DSIP is a defined linear nonapeptide suitable for investigations involving peptide characterization and structure-activity relationships.
Research Applications
| Research Area | In Vitro Application |
|---|---|
| Peptide Chemistry | Sequence and structural characterization |
| Neuropeptide Research | Exploratory cellular response studies |
| Peptide Stability | Degradation and analytical characterization |
| Structure-Activity Research | Comparison of DSIP and modified analogues |
References
- Schoenenberger GA, Monnier M. (1977). Characterization of a Delta-Electroencephalogram (-Sleep)-Inducing Peptide. Proceedings of the National Academy of Sciences. PubMed PMID: 265572.
- Schoenenberger GA, Maier PF, Tobler HJ, Wilson K, Monnier M. (1978). The Delta EEG (Sleep)-Inducing Peptide (DSIP). XI. Amino-Acid Analysis, Sequence, Synthesis and Activity of the Nonapeptide. Pflügers Archiv. PubMed PMID: 568769.
- Kovalzon VM, Strekalova TV. (2006). Delta Sleep-Inducing Peptide (DSIP): A Still Unresolved Riddle. Journal of Neurochemistry. View review.
Certificate of Analysis (COA)
Batch-specific documentation should verify amino acid sequence, compound identity, purity, molecular characteristics, and actual peptide content.
For information about available documentation, contact Peptide Lives.
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