Description
PE-22-28 Technical Overview
PE-22-28 is an experimental peptide associated with the activity of the serpin-derived peptide Spadin, investigated in neuroscience research involving the two-pore-domain potassium channel TREK-1.
Spadin-related peptides have attracted research interest because experimental studies have examined their interaction with TREK-1-associated signaling and neuronal responses.
PE-22-28 is a distinct peptide fragment or analogue whose specific properties depend on the exact amino acid sequence and terminal modifications.
Compound Specifications
| Property | Value |
|---|---|
| Compound Name | PE-22-28 |
| Classification | Experimental neuroactive peptide |
| Related Research Compound | Spadin |
| Research Target | TREK-1 potassium channel-related signaling |
| Exact Sequence | Requires structural identification |
| Vial Content | 10mg |
| Research Category | Neuroscience Research |
Storage and Handling
- Follow manufacturer storage recommendations.
- Protect from moisture and light.
- Use procedures appropriate for synthetic neuroactive peptides.
Lyophilized Format
PE-22-28 may be manufactured in lyophilized form. Physical characteristics depend on the preparation.
Research Use Disclaimer
PE-22-28 is not FDA-approved for human therapeutic use. Not intended for human or veterinary administration.
Frequently Asked Questions
What Is PE-22-28?
An experimental peptide associated with Spadin-related neuroscience research.
What Is TREK-1?
A two-pore-domain potassium channel involved in neuronal membrane excitability.
Is PE-22-28 the Same as Spadin?
Not necessarily. They are related but distinct peptide designations.
What Research Areas Involve PE-22-28?
TREK-1 channel pharmacology and neuronal signaling.
Research Overview
Spadin-associated peptides have been studied in experimental neuroscience.
TREK-1 Research
Experimental studies investigate potassium channel-related signaling.
Neuronal Excitability
Research explores the relationship between TREK-1 and membrane electrical properties.
Peptide Pharmacology
Structure-activity studies investigate related peptide fragments.
Research Applications
| Research Area | In Vitro Application |
|---|---|
| TREK-1 | Potassium channel studies |
| Neuronal Biology | Membrane signaling assays |
| Peptide Chemistry | Fragment characterization |
References
- Mazella J, Pétrault O, Lucas G, et al. (2010). Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design. PLoS Biology. View publication.
Certificate of Analysis (COA)
Documentation should establish the exact PE-22-28 sequence, molecular identity, purity, and content.
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