Description
Semax Technical Overview
Semax is a synthetic heptapeptide derived from the adrenocorticotropic hormone (ACTH) fragment ACTH(4–7), extended with the Pro-Gly-Pro sequence.
The peptide has been studied in experimental neuroscience research involving neurotrophin gene expression, neuronal responses to stress, and molecular signaling pathways.
Published animal investigations have examined changes in brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and associated gene expression following Semax exposure.
These findings do not establish that a research-grade Semax preparation improves human memory, concentration, or neurological recovery.
Compound Specifications
| Property | Value |
|---|---|
| Compound Name | Semax |
| Classification | Synthetic ACTH-derived heptapeptide |
| Amino Acid Sequence | H-Met-Glu-His-Phe-Pro-Gly-Pro-OH |
| One-Letter Sequence | MEHFPGP |
| Sequence Length | 7 residues |
| Structural Origin | ACTH(4–7) extended with Pro-Gly-Pro |
| Source | Synthetic |
| Vial Content | 10mg |
| Research Category | Neuroscience Research |
These specifications refer to unmodified Semax, not N-acetyl Semax amidate or other derivatives.
Storage and Handling
- Store according to manufacturer stability recommendations.
- Protect from moisture, light, and unnecessary temperature fluctuations.
- Maintain appropriate laboratory handling procedures.
Lyophilized Format
Semax may be manufactured in lyophilized form. Storage conditions depend on formulation and packaging.
Research Use Disclaimer
Semax is not FDA-approved for human therapeutic use. The research material is not intended for human or veterinary administration.
Frequently Asked Questions
What Is Semax?
Semax is a synthetic seven-amino-acid peptide derived from a portion of ACTH.
What Is Its Amino Acid Sequence?
MEHFPGP.
Does Semax Contain ACTH’s Full Sequence?
No. It includes a short ACTH-derived fragment and an additional Pro-Gly-Pro sequence.
What Research Areas Involve Semax?
Neurotrophin expression, gene regulation, neuronal stress responses, and experimental neuroscience.
Is Semax Approved by the FDA?
No.
Research Overview
Semax has been investigated in animal experiments evaluating neurotrophin-associated molecular responses.
BDNF Research
Experimental studies have examined Semax-associated changes in BDNF gene expression in selected rat brain regions.
NGF Research
Research has also investigated nerve growth factor transcription in laboratory models.
Experimental Ischemia Research
Animal studies have evaluated neurotrophin-related signaling after experimentally induced cerebral ischemia.
Peptide Bioregulation
The defined structure of Semax provides a model for studying relationships between short peptide sequences and molecular signaling.
Research Applications
| Research Area | In Vitro Application |
|---|---|
| Neurotrophin Research | BDNF and NGF expression assays |
| Gene Regulation | Transcriptional response analysis |
| Neuronal Biology | Experimental cell signaling |
| Peptide Chemistry | ACTH analogue characterization |
References
- Agapova et al. — Neurotrophin Gene Expression in Rat Brain Under the Action of Semax.
- Dmitrieva et al. — Semax and Pro-Gly-Pro Activate the Transcription of Neurotrophins and Their Receptor Genes After Cerebral Ischemia.
Certificate of Analysis (COA)
Documentation should confirm the sequence, molecular identity, purity, and content of the supplied Semax preparation.
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