Description
Thymosin Alpha-1 Technical Overview
Thymosin Alpha-1 (Tα1), also known as Thymalfasin, is a 28-amino-acid peptide originally isolated from thymic tissue. Its N-terminal serine residue is acetylated, an important feature of the native peptide structure.
The peptide has been investigated in laboratory immunology involving Toll-like receptor signaling, dendritic cell maturation, cytokine regulation, and immune-cell responses.
Experimental studies have examined Thymosin Alpha-1-associated changes in signaling pathways including MyD88, p38 MAPK, NF-κB, and selected cytokine networks.
Compound Specifications
| Property | Value |
|---|---|
| Compound Name | Thymosin Alpha-1 |
| Alternative Names | Thymalfasin, Tα1 |
| CAS Number | 62304-98-7 |
| PubChem CID | 16130571 |
| Molecular Formula | C129H215N33O55 |
| Molecular Weight | 3108.3 g/mol |
| Amino Acid Sequence | Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN |
| Sequence Length | 28 amino acid residues |
| N-Terminal Modification | Acetylated |
| Classification | Thymic peptide |
| Source | Synthetic research preparation |
| Vial Content | 5mg |
Storage and Handling
- Store according to manufacturer-validated stability conditions.
- Protect from moisture and unnecessary light exposure.
- Keep containers securely sealed.
- Use suitable laboratory peptide handling procedures.
Lyophilized Format
Thymosin Alpha-1 may be supplied in lyophilized form. Freeze-drying can support stability under appropriate storage conditions.
Research Use Disclaimer
Thymosin Alpha-1 is described exclusively for laboratory research purposes. This preparation is not represented as an FDA-approved therapeutic product and is not intended for human or veterinary administration.
Frequently Asked Questions
What Is Thymosin Alpha-1 5mg?
A research preparation of the 28-residue peptide Thymosin Alpha-1.
What Is Thymalfasin?
Thymalfasin is another name for Thymosin Alpha-1.
What Is the Molecular Weight?
Approximately 3108.3 g/mol for the unmodified salt-free molecular entity.
What Research Areas Involve TA1?
Dendritic cell signaling, TLR pathways, cytokine regulation, and immune-cell biology.
Is TA1 the Same as Thymalin?
No. Thymosin Alpha-1 is a defined peptide, whereas traditional Thymalin is a mixture of thymus-derived peptides.
Thymosin Alpha-1 Research Overview
Thymosin Alpha-1 has been investigated for its effects on cellular immune signaling. Its activity has been examined using dendritic cells, macrophages, and additional experimental cell populations.
Dendritic Cell Maturation
Research has reported changes in maturation-associated markers and cytokine output in dendritic cell culture systems.
Toll-Like Receptor Research
Studies have investigated Thymosin Alpha-1-associated responses involving TLR pathways and downstream intracellular mediators.
Intracellular Signaling
Experimental investigations have examined p38 MAPK, NF-κB, and other signaling pathways under defined culture conditions.
Research Applications
| Research Area | In Vitro Application |
|---|---|
| TLR Research | Receptor co-stimulation assays |
| Dendritic Cells | Maturation marker analysis |
| Cytokine Regulation | IL-10 and IL-12 measurements |
| Cellular Signaling | MAPK and NF-κB pathway studies |
References
- Romani L, et al. (2004). Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling. Blood. View publication.
- Huang Y, et al. (2004). The modulation of thymosin alpha 1 in the maturation, differentiation and function of murine bone marrow-derived dendritic cells. International Immunopharmacology. View publication.
- Li J, Liu CH, Wang FS. (2010). Thymosin alpha 1: biological activities, applications and genetic engineering production. Peptides. View publication.
Certificate of Analysis (COA)
Batch documentation should confirm the peptide sequence, N-terminal acetylation, molecular identity, purity, and actual content.
For available documentation, contact Peptide Lives.
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